| WEEK 1 | | | |
| SEPT. 12 — FOX NFL SUNDAY DOUBLEHEADER | | |
| 1:00 PM ET | Philadelphia Eagles at Atlanta Falcons | | |
| Minnesota Vikings at Cincinnati Bengals | | |
| San Francisco 49ers at Detroit Lions | | |
| Seattle Seahawks at Indianapolis Colts | | |
| | | |
| 4:25 PM ET | Green Bay Packers at New Orleans Saints | | |
| Denver Broncos at New York Giants | | |
| | | |
| WEEK 2 | | | |
| SEPT. 19 — FOX NFL SUNDAY SINGLEHEADER | | |
| 1:00 PM ET | Los Angeles Rams at Indianapolis Colts | | |
| Buffalo Bills at Miami Dolphins | | |
| New Orleans Saints at Carolina Panthers | | |
| San Francisco 49ers at Philadelphia Eagles | | |
| Cincinnati Bengals at Chicago Bears | | |
| | | |
| 4:05 PM ET | Atlanta Falcons at Tampa Bay Buccaneers | | |
| Minnesota Vikings at Arizona Cardinals | | |
| | | |
| WEEK 3 | | | |
| SEPT. 26 — FOX NFL SUNDAY DOUBLEHEADER | | |
| 1:00 PM ET | New Orleans Saints at New England Patriots | | |
| Chicago Bears at Cleveland Browns | | |
| Atlanta Falcons at New York Giants | | |
| Washington Football Team at Buffalo Bills | | |
| Arizona Cardinals at Jacksonville Jaguars | | |
| | | |
| 4:25 PM ET | Tampa Bay Buccaneers at Los Angeles Rams | | |
| Seattle Seahawks at Minnesota Vikings | | |
| | | |
| WEEK 4 | | | |
| OCT. 3 — FOX NFL SUNDAY SINGLEHEADER | | |
| 1:00 PM ET | Carolina Panthers at Dallas Cowboys | | |
| New York Giants at New Orleans Saints | | |
| Detroit Lions at Chicago Bears | | |
| Washington Football Team at Atlanta Falcons | | |
| | | |
| 4:05 PM ET | Seattle Seahawks at San Francisco 49ers | | |
| Arizona Cardinals at Los Angeles Rams | | |
| | | |
| WEEK 5 | | | |
| OCT. 7 — THURSDAY NIGHT FOOTBALL | | |
| 8:20 PM ET | *Los Angeles Rams at Seattle Seahawks | | |
| | | |
| OCT. 10 — FOX NFL SUNDAY DOUBLEHEADER | | |
| 1:00 PM ET | Green Bay Packers at Cincinnati Bengals | | |
| Denver Broncos at Pittsburgh Steelers | | |
| Philadelphia Eagles at Carolina Panthers | | |
| Detroit Lions at Minnesota Vikings | | |
| | | |
| 4:25 PM ET | New York Giants at Dallas Cowboys | | |
| San Francisco 49ers at Arizona Cardinals | | |
| | | |
| WEEK 6 | | | |
| OCT. 14 — THURSDAY NIGHT FOOTBALL | | |
| 8:20 PM ET | *Tampa Bay Buccaneers at Philadelphia Eagles | | |
| | | |
| OCT. 17 — FOX NFL SUNDAY SINGLEHEADER | | |
| 1:00 PM ET | Green Bay Packers at Chicago Bears | | |
| Los Angeles Rams at New York Giants | | |
| Minnesota Vikings at Carolina Panthers | | |
| Cincinnati Bengals at Detroit Lions | | |
| | | |
| 4:05 PM ET | Arizona Cardinals at Cleveland Browns | | |
| | | |
| WEEK 7 | | | |
| OCT. 21 — THURSDAY NIGHT FOOTBALL | | |
| 8:20 PM ET | *Denver Broncos at Cleveland Browns | | |
| | | |
| OCT. 24 — FOX NFL SUNDAY SINGLEHEADER | | |
| 1:00 PM ET | Washington Football Team at Green Bay Packers | | |
| Atlanta Falcons at Miami Dolphins | | |
| Carolina Panthers at New York Giants | | |
| | | |
| 4:05 PM ET | Detroit Lions at Los Angeles Rams | | |
| Philadelphia Eagles at Las Vegas Raiders | | |
| | | |
| WEEK 8 | | | |
| OCT. 28 — THURSDAY NIGHT FOOTBALL | | |
| 8:20 PM ET | *Green Bay Packers at Arizona Cardinals | | |
| | | |
| OCT. 31 — FOX NFL SUNDAY DOUBLEHEADER | | |
| 1:00 PM ET | San Francisco 49ers at Chicago Bears | | |
| Philadelphia Eagles at Detroit Lions | | |
| Los Angeles Rams at Houston Texans | | |
| Carolina Panthers at Atlanta Falcons | | |
| | | |
| 4:25 PM ET | Tampa Bay Buccaneers at New Orleans Saints | | |
| Washington Football Team at Denver Broncos | | |
| | | |
| WEEK 9 | | | |
| NOV. 4 — THURSDAY NIGHT FOOTBALL | | |
| 8:20 PM ET | *New York Jets at Indianapolis Colts | | |
| | | |
| NOV. 7 — FOX NFL SUNDAY DOUBLEHEADER | | |
| 1:00 PM ET | Denver Broncos at Dallas Cowboys | | |
| Minnesota Vikings at Baltimore Ravens | | |
| Atlanta Falcons at New Orleans Saints | | |
| Houston Texans at Miami Dolphins | | |
| | | |
| 4:25 PM ET | Green Bay Packers at Kansas City Chiefs | | |
| Arizona Cardinals at San Francisco 49ers | | |
| | | |
| WEEK 10 | | | |
| NOV. 11 — THURSDAY NIGHT FOOTBALL | | |
| 8:20 PM ET | *Baltimore Ravens at Miami Dolphins | | |
| | | |
| NOV. 14 — FOX NFL SUNDAY SINGLEHEADER | | |
| 1:00 PM ET | Atlanta Falcons at Dallas Cowboys | | |
| Tampa Bay Buccaneers at Washington Football Team | | |
| Detroit Lions at Pittsburgh Steelers | | |
| | | |
| 4:05 PM ET | Minnesota Vikings at Los Angeles Chargers | | |
| Carolina Panthers at Arizona Cardinals | | |
| | | |
| WEEK 11 | | | |
| NOV.18 — THURSDAY NIGHT FOOTBALL | | |
| 8:20 PM ET | *New England Patriots at Atlanta Falcons | | |
| | | |
| NOV. 21 — FOX NFL SUNDAY DOUBLEHEADER | | |
| 1:00 PM ET | Green Bay Packers at Minnesota Vikings | | |
| New Orleans Saints at Philadelphia Eagles | | |
| Washington Football Team at Carolina Panthers | | |
| San Francisco 49ers at Jacksonville Jaguars | | |
| Detroit Lions at Cleveland Browns | | |
| | | |
| 4:25 PM ET | Dallas Cowboys at Kansas City Chiefs | | |
| Arizona Cardinals at Seattle Seahawks | | |
| | | |
| WEEK 12 | | | |
| NOV. 25 — THANKSGIVING | | |
| 12:30 PM ET | Chicago Bears at Detroit Lions | | |
| | | |
| NOV. 28 — FOX NFL SUNDAY DOUBLEHEADER | | |
| 1:00 PM ET | Philadelphia Eagles at New York Giants | | |
| Tampa Bay Buccaneers at Indianapolis Colts | | |
| Carolina Panthers at Miami Dolphins | | |
| | | |
| 4:25 PM ET | Los Angeles Rams at Green Bay Packers | | |
| Minnesota Vikings at San Francisco 49ers | | |
| | | |
| WEEK 13 | | | |
| DEC. 2 — THURSDAY NIGHT FOOTBALL | | |
| 8:20 PM ET | *Dallas Cowboys at New Orleans Saints | | |
| | | |
| DEC. 5 — FOX NFL SUNDAY SINGLEHEADER | | |
| 1:00 PM ET | New York Giants at Miami Dolphins | | |
| Tampa Bay Buccaneers at Atlanta Falcons | | |
| Arizona Cardinals at Chicago Bears | | |
| Los Angeles Chargers at Cincinnati Bengals | | |
| | | |
| 4:05 PM ET | Washington Football Team at Las Vegas Raiders | | |
| | | |
| WEEK 14 | | | |
| DEC. 9 — THURSDAY NIGHT FOOTBALL | | |
| 8:20 PM ET | *Pittsburgh Steelers at Minnesota Vikings | | |
| | | |
| DEC. 12 — FOX NFL SUNDAY SINGLEHEADER | | |
| 1:00 PM ET | Dallas Cowboys at Washington Football Team | | |
| New Orleans Saints at New York Jets | | |
| Seattle Seahawks at Houston Texans | | |
| Atlanta Falcons at Carolina Panthers | | |
| | | |
| 4:05 PM ET | New York Giants at Los Angeles Chargers | | |
| Detroit Lions at Denver Broncos | | |
| | | |
| WEEK 15 | | | |
| DEC. 16 — THURSDAY NIGHT FOOTBALL | | |
| 8:20 PM ET | *Kansas City Chiefs at Los Angeles Chargers | | |
| | | |
| DEC. 19 — FOX NFL SUNDAY DOUBLEHEADER | | |
| 1:00 PM ET | Green Bay Packers at Baltimore Ravens | | |
| Dallas Cowboys at New York Giants | | |
| Arizona Cardinals at Detroit Lions | | |
| | | |
| 4:25 PM ET | Seattle Seahawks at Los Angeles Rams | | |
| | | |
| WEEK 16 | | | |
| DEC. 25 — CHRISTMAS DAY | | |
| 4:30 PM ET | *Cleveland Browns at Green Bay Packers | | |
| | | |
| DEC. 26 — FOX NFL SUNDAY SINGLEHEADER | | |
| 1:00 PM ET | Los Angeles Rams at Minnesota Vikings | | |
| New York Giants at Philadelphia Eagles | | |
| Tampa Bay Buccaneers at Carolina Panthers | | |
| Detroit Lions at Atlanta Falcons | | |
| | | |
| 4:05 PM ET | Chicago Bears at Seattle Seahawks | | |
| | | |
| WEEK 17 | | | |
| JAN. 2 — FOX NFL SUNDAY DOUBLEHEADER | | |
| 1:00 PM ET | Arizona Cardinals at Dallas Cowboys | | |
| Tampa Bay Buccaneers at New York Jets | | |
| Philadelphia Eagles at Washington Football Team | | |
| Carolina Panthers at New Orleans Saints | | |
| Atlanta Falcons at Buffalo Bills | | |
| | | |
| 4:25 PM ET | Los Angeles Rams at Baltimore Ravens | | |
| Detroit Lions at Seattle Seahawks | | |
| | | |
| WEEK 18 | | | |
| JAN. 9 — FOX NFL SUNDAY DOUBLEHEADER | | |
| 1:00 PM ET | Dallas Cowboys at Philadelphia Eagles | | |
| Washington Football Team at New York Giants | | |
| Green Bay Packers at Detroit Lions | | |
| Chicago Bears at Minnesota Vikings | | |
| Carolina Panthers at Tampa Bay Buccaneers | | |
| New Orleans Saints at Atlanta Falcons | | |
| | | |
| 4:25 PM ET | Seattle Seahawks at Arizona Cardinals | | |
| San Francisco 49ers at Los Angeles Rams | | |
| | | |
| PLAYOFFS | | | |
| | | |
| NFC Wild Card Game | | |
| Saturday, January 15 or Sunday, January 16, 2022 | | |
| | | |
| NFC Divisional Playoff Games | | |
| Saturday, January 22 or Sunday, January 23, 2022 | | |
| | | |
| NFC Championship Game | | |
| Sunday, January 30, 2022 | | |
